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Medical NBDE-II : Dental Board Exams Part II Exam

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Exam Number : NBDE-II
Exam Name : Dental Board Exams Part II
Vendor Name : Medical
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NBDE-II test Format | NBDE-II Course Contents | NBDE-II Course Outline | NBDE-II test Syllabus | NBDE-II test Objectives

The NBDE Part II is a comprehensive examination consisting of 500 items. For each discipline, approximately 80% of the items are stand-alone, while approximately 20% are interdisciplinary and case-based. A case consists of a patient scenario, patient history, and a set of discipline-based items relevant to the scenario. NBDE items are developed by test construction teams composed of subject-matter experts in accordance with examination specifications approved by the JCNDE.
The Universal/National System for tooth notation that has been adopted by the American Dental Association is used on all National Board Examinations. This system is a sequential tooth numbering system, designating the permanent dentition (numbers 1-32), and the primary dentition (letters A-T).
In the June 2018 issue of the Journal of Periodontology the American Academy of Periodontology (AAP) published updates to its Classification of Periodontal and Peri-Implant Diseases and Conditions. Candidates completing examinations published through the Department of Testing Servicesincluding those overseen by the Joint Commission on National Dental Examinations or by the American Dental Associationcontinue to be based on the prior (i.e., 1999) AAP disease classification. Candidates will be notified when examinations are updated to reflect the new terminology.
Discipline-Based Component (400 items)
The test items that comprise the discipline-based component are derived from the following disciplines:
1. Endodontics
2. Operative Dentistry
3. Oral and Maxillofacial Surgery/ Pain Control
4. Oral Diagnosis
5. Orthodontics/Pediatric Dentistry
6. Patient Management
7. Periodontics
8. Pharmacology
9. Prosthodontics
Case-Based Component (100 items)
The case-based component of the NBDE Part II presents items dealing with genuine patients. The patient cases are developed to include the following approximate distribution: adult patients 70%; child patients 30%. A minimum of 15% of case-based test questions will address the medical management of compromised adults and children. A compromised patient is defined as a person whose health status requires modification of standard treatment. Each case presentation in the examination consists of:
1. synopsis of a patients health and social histories,
2. patient dental charting,
3. diagnostic radiographs, and
4. clinical photographs of the patient (when necessary).
Each case contains from 10 to 15 questions about various aspects of the patients dental care. These questions-- totaling 100 across all cases-- might derive from any of the biomedical sciences and clinical disciplines, including Patient Management. The proportion stemming from any particular discipline depends upon the nature of the case itself. For example, the case of an elderly adult might be based upon Maxillofacial Surgery/Pain Control, Prosthodontics, and Operative Dentistry, whereas a childs case might derive from Orthodontics, Pediatric Dentistry, and Patient Management. In responding to case-based items, the candidate must:
1. interpret the findings and information provided.
2. identify problems and make diagnoses.
3. select materials, technique, and armamentarium.
4. apply treatment.
5. evaluate progress and complications.
6. establish procedures for prevention and maintenance.
Endodontics* (36 items)
Case Clinical Diagnosis, Case Selection, Treatment Planning, and Patient Management
Basic Endodontic Treatment Procedures
Procedural Complications
Traumatic Injuries
Adjunctive Endodontic Therapy
Post-Treatment Evaluation
Operative Dentistry (44 items)
Dental Caries
Examination, Diagnosis, & Treatment Planning
General Operative Procedures
Preparation of Cavities
Restoration of Prepared Cavities
Oral And Maxillofacial Surgery/Pain Control (52 items)
Anxiety and Pain Control
Medical Assessment and Emergency Care
Treatment Plan
Orthodontics/Pediatric Dentistry (44 items)
Individual Tooth Pathology
Supporting Tissue Pathology
Dentofacial Variations
Systemic Pathology
Patient Management (53 items)
Communication and Interpersonal Skills
Anxiety and Pain Control
Health Behavior Change
Disabled and Medically Compromised
Prevention of Oral Diseases
Evaluation of Dental Literature
Infection Control
Materials and Equipment Safety
Professional Responsibility/Liability
Practice Management
Periodontics (46)
Treatment Planning
Prevention and Maintenance
Pharmacology (35 items)
General Principles
Central Nervous System
Local Anesthetics
Antihistamines and Autocoids
Prosthodontics (48 items)
General Considerations
Complete and Removable Partial Denture Prosthodontics
Fixed Partial Prosthodontics

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Medical II outline

UVA researchers overturn ordinary knowledge on motion of key hormone receptors inside cells | NBDE-II genuine Questions and Practice Questions

Researchers at the college of Virginia school of medication have overturned usual knowledge on the workings of a must-have hormone receptors within cells, a discovering that might increase drug development for diabetes and linked metabolic disorders, cancer and different diseases.

UVA researchers overturn conventional wisdom on action of key hormone receptors within cells

Senior researcher Irina M. Bochkis is an assistant professor of pharmacology within the UVA school of medication. (picture through Dan Addison, college of Virginia)

The scientists in UVA’s department of Pharmacology define a wholly new paradigm to clarify the activation of a type of hormone receptor, known as category II receptors, discovered inside their cells’ nuclei. These receptors play essential roles in their body’s use of ldl cholesterol and glucose, amongst different essential techniques.

“Nuclear receptors are the handiest class of DNA-binding proteins that are druggable. Drug building has been concentrated completely on designing artificial hormones that could change the natural ones and activate the receptor because everybody believed that binding of the receptor to DNA was constant,” said senior researcher Irina M. Bochkis, PhD. “To everybody’s shock, they discover that DNA has to be opened for the receptor to bind. For distinctive artificial hormones, diverse materials of DNA become available, some leading to really helpful and others to dangerous effects. If they can target the places in DNA that lead to favorable outcomes and stay away from getting access to websites that could cause opposed ones, the efficacy of the medication could be significantly enhanced.”

knowing hormone motion

Scientists have thought that two critical hormone receptors, referred to as FXR & LXRα, had been permanently certain to DNA inner the nuclei of their cells. however Bochkis and her group found that this wasn’t the case. in its place, a fancy cascade of events is required to prompt the hormone receptors, they decided.

A key player in these court cases is a protein referred to as Foxa2. Their DNA is locked up interior their chromosomes in a kind called chromatin; Foxa2 turns the key in that lock. This factors the chromatin to open temporarily. once this occurs, hormone binding can turn up, the UVA scientists determined.

Foxa2 plays different critical roles as neatly, they found. After it opens the chromatin, it ensures the activation of the correct receptor and suppresses a competing receptor. Computational evaluation by researcher Nihal Reddy, an undergraduate pupil, become important to show this aspect.

according to their findings, the researchers have dubbed Foxa2 a “gatekeeper” in the hormone-binding process. And it might act as the gatekeeper for other class II receptors in the nucleus as neatly, the researchers conclude.

“americans didn't trust us as a result of they'd a distinct mannequin they relied on for thus lengthy. Their preliminary findings described simplest LXRα. They decided to encompass FXR to display Foxa2 opens DNA for diverse receptors in a typical mechanism,” referred to researcher Xiaolong Wei, the co-first creator of a brand new scientific paper outlining the findings. “That involved doubling the amount of a large number of genomic experiments they performed, which took me a while to finished. however is price it.”

a further brilliant discovering: in the past, scientists had concept that ligand (or artificial hormone) binding leads simplest to activation of genes by the receptor. however the new work from Bochkis and her collaborators turns that belief on its ear. Ligand binding forces Foxa2 and the nuclear receptor to have interaction; this results in opening of DNA by way of Foxa2 and subsequent receptor binding and gene activation. Foxa2 and the nuclear receptor do not engage without the ligand, they found.

Now after I train endocrinology, i can ultimately reveal the appropriate model of receptor activation as an alternative of asserting that the textbook has no longer stored up with research. Their findings will trade the way americans approach drug design and with a bit of luck lead to formulations that lack detrimental facet results.”

Irina M. Bochkis, PhD, Senior Researcher

Findings published

The researchers have posted their findings in the scientific journal Molecular Metabolism. The analysis team consisted of Jessica Kain, Xiaolong Wei, Nihal A. Reddy, Andrew J. price, Claire Woods and Irina Bochkis.

The research become supported with the aid of the country wide Institutes of fitness’s country wide Diabetes and Digestive and Kidney diseases Institute, R01 award DK121059.


Journal reference:

Kain, J., et al. (2021) Pioneer component Foxa2 allows for ligand-stylish activation of classification II nuclear receptors FXR and LXRα. Molecular Metabolism.

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